I used to, but I have a burrowing fish and he seems to do a really good job of keeping the sand stirred up, but I shifted the sand around in the tank (another fish had been trying to build some kind of a burrow, and heaped the sand in an akward spot), and there wasn't really that much gunk that came out of the sand. From when I first started the tank I vacuumed every water change, and I havent really noticed a change from when I stopped, just extra work.
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