Small update - First negative. The fluconazol did kill a nice sponge I had. Those who have been to J&L have seen the cube take before you enter the fish/coral area that has a lot of that deep purple plating sponge, well I bought a frag of it about a year ago and I'm guessing the sponge obsorbed the fluc and died.
Not a huge deal but Id remove sponges in the future if I ever get another...
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