We are in the middle of building a cube (24x24x18) and the biggest "con" would have to be the footprint under the stand. Its really tough to fit everything needed to run a proper reef under the stand.
You need room for sump, skimmer, reactors, return pump, doser, dosing containers, auto-top-off, powerbar, etc...
It can be done, it just requires careful planning.
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