Love this build, looks great! The only time you run in to serious issues with a herbie (as far as I know) is when you start adding T's to the drain line. As mentioned, the pipes attached to your return pump don't affect it beyond the fact that any add-ons and doodads connected to the manifold will affect your flow rate, so if you get it all tuned up then disconnect a GFO reactor to change the media out you might see the water level in your overflow rise a bit until you put the reactor back online.
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