Guess I should have clarified my response some.
In a hydraulic system if all other values are kept the same, including pressure and friction, the volume of flow will be reduced by the same ratio as the area. There are many other factors that can and will contribute to this, if you are looking to maintain maximum pump life and flow rate, keep the system restrictions to a minimum and as far away from the pump as possible, the longer the pipe is held at 2" the better.
In most pump driven system flow rate is maintained closer than the volume reduction due to increased pressure at the pump. Increasing the pressure increases the work the pump must do to maintain the flow rate and therefore reduces the maximum life expectancy.
If you are going to tee off do so before the reduction to reduce pressure at the pump and maintain pump life.
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