I used something called Herbtana a while ago. Claims to be herbal (but god only knows what else is in it)
It recommends a ten day treatment. It says to turn off your skimmer, I thought just for an hour or two after dosage but on day two it started to bubble over so I left it off. I continued to dose until day 6 where I stopped, ick (on my regal tang) appeared to be gone and I was really anxious to turn my skimmer back on. The ick hasn't returned thus far, and my corals or inverts never showed any sign of discomfort.
Might be worth looking into, or hearing some more opinions on.
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