you can run both but first you half to start with bio pellets for 4-6 weeks then start the gfo. you need the nitrate part of the cycle to be going then the phosphate part so i was told and my tank is doing fine started with 50 ppm nitrate now at 5-10 ppm in two weeks.was running gfo first just swiched out gfo for bio pellets now am getting ready to start gfo
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