It isn't necessary to dose with interceptor more than once, so long as you use the correct dosage.
When most of the literature on red bugs was originally posted, very little was known about their life cycle. Since then, it has been found that red bugs are live bearers and do not have an egg or larval stage that could have been resistant to milbemycin oxime, the active ingredient in Interceptor. It was only suggested to do a 2nd and 3rd treatment with interceptor in order to kill off the 2nd generation of red bugs that could have possibly hatched after the initial treatment. Since we now know that red bugs do not go through such a stage in life, one good treatment with interceptor is enough to wipe them out of your reef.
Expect to loose 99% of your pod population along with all of your acro crabs, sally light foots, and emerald crabs. Hermit crabs are not true crabs and as such are not effected by the interceptor. Other inverts such as cleaner shrimps, peppermints, snails, and urchins should all be fine as well as the sea hare. If you'd feel better removing the sea hare due to their known toxicity upon death, it probably wouldn't hurt.
Hope the info helps.
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