It depends on a few things, first off as stated length for sure as well as bracing but it's not about safety with acrylic. You could build a tank 4 feet tall with 1/2" and it would easily hold but it's the bow you have to worry about. Acrylic is softer than glass and will bow and bulge more which creates distortion. I wouldn't go any bigger than 4 feet in length and 2 feet in height using 1/2". Remember Acrylic is clear you can go as thick as you want without sacrificing clarity. Although it's stronger than glass an acrylic tank should use thicker material than a glass tank.
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