I have had good luck with Joe's Juice. It has killed all the little aptasia (non seem to have come back) and has not harmed anything else in the tank. I'm not sure how it would do on a large one. You could always physically remove the large one, and zap any small ones with Joe's Juice that might show up later.
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120 g (675 W mh), 27 g refugium (65 w pc), yellow tang, regal tang, 2 osc. clowns, 4 chromis, 1 blue damsel, 1 conch, 2 pepp. shrimp, 2 cleaner shrimp, margaritta and astraea snails, 2 hermit crabs, 1 sea hare, mushrooms, zooantids, green frog spawn, colt and finger leathers, plate coral. bubble coral
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