I have 4 nano's running right now although the 12g just crashed this week because of grape calurpa going sexual and I lost everything in the tank.  I have a 10g, 24g and a 20g at work.  I do 50% weekly water changes as none except the one at work have a skimmer.  I always test my change water and add any additives to that to bring it to the levels that I want so never add anything directly to the tanks themselves. 
		
	
		
		
		
		
		
	
		
		
	
	
	 |