I ran a sugar sand DSB for a few years and it eventually became a nutrient factory and I had to pull it out. Initially, there was a lot of hype about it, with some claiming that with a good selection of detrivores it would make a near self-sustaining ecosystem. As time passed more and more people started having problems. Personally, I would not run one again. Also keep in mind that due to the amount of sand required it is basically the most expensive option.
IMO go either bare bottom or a thinner layer of a coarser substrate that allows you to siphon/vacuum out detritus.
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