just looked at this, i dont get how would this work for 4500sf?
to me i would think to service 4500sf it would need to be inline with the hvac?

or would it actually work passively? like it removes moisture from the air in one room which effectively lowers the overall moisture level in the house as moisture from throughout moves around until all the air is the same level?

I think you hit the nail on the head..
gases/liguids all tend to equalize particles in suspension

I've got a 180g tank in my kitchen, and it evaporates about 2-3 gallons a day. Been running since December 2019. I don't do anything about it, and haven't noticed any issues at all with moisture. not even condensation on the windows. Haven't measured the moisture level in my place, so no idea where it sits.

Im at a few gallons a day...
I dont see condensation either...
I do feel the humidity when i enter the house...
Especially after my wife mentioned to me!
LMAOOOO

Anyhoo since then ive peeked at my Nest thermo and it indicates 50-60% which even just sounds high to me.

I guess maybe just run a dehumidifier in the furnace room so it can drain freely and see what happens? Just doesnt sound cost effective to have to run this thing constantly.